10/30/2023 0 Comments Qq download latest version![]() ![]() From a clinical perspective, our findings corroborate the neurological safety of ECT. Thus, the manifestation of NSS in MDD seems to be independent of illness duration and pharmacological and electroconvulsive antidepressant treatment. Importantly, we found no change in NSS after on average eleven sessions of ECT. The degree of NSS in both patient groups did not differ. We found that both chronically depressed, medicated MDD patients and acutely depressed, unmedicated MDD patients showed more NSS than healthy controls. In addition, NSS were assessed once in acutely depressed, unmedicated MDD patients ( n = 16) and healthy controls ( n = 20). To test this hypothesis, NSS were assessed in chronically depressed, medicated MDD patients before ( n = 23) and after ( n = 18) a series of electroconvulsive therapy (ECT). We thus predicted that patients show more NSS than healthy controls, irrespective of illness duration and antidepressant treatment. We hypothesized that NSS are relatively stable trait markers of MDD. The significance of neurological soft signs (NSS) in major depressive disorder (MDD) remains unclear and the stability of NSS in relation to antidepressant treatment has never been investigated. ![]()
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